Comparison of Simparica, K9 Advantix II, and Frontline Plus
| Feature | Simparica | K9 Advantix II | Frontline Plus |
|---|---|---|---|
| Type | Oral chewable tablet | Topical solution | Topical solution |
| Protection Duration | 30–35 days | 30 days | 30 days |
| Parasites Targeted | Fleas, ticks, mange mites | Fleas, ticks, mosquitoes, biting flies, chewing lice | Fleas (all life stages), ticks, chewing lice |
| Speed of Action | Kills fleas within 3 hours; ticks within 8 hours | Kills fleas, ticks, and mosquitoes within 12 hours | Kills fleas within 24 hours; ticks within 48 hours |
| Waterproof? | Yes (oral) | Yes (topical) | Yes (topical) |
| Advantages | - Fast-acting and long-lasting | - Broad spectrum (includes mosquitoes and biting flies) | - Effective on all flea life stages |
| - Easy to administer (oral tablet) | - Repels as well as kills parasites | - Safer for households with cats | |
| - Useful for mange mites | - Breaks flea lifecycle | - Good for dogs that swim frequently | |
| Disadvantages | - Requires a prescription | - Toxic to cats; must keep cats away from treated dogs for 24 hours | - Slower action against ticks compared to K9 Advantix II |
| - Potential side effects: vomiting, diarrhea, tremors, seizures | - May cause skin irritation or gastrointestinal upset | - May cause mild skin irritation | |
| - Not evaluated for pregnant/lactating dogs |
Summary
Simparica: Best for fast action and oral administration but requires a prescription and may have neurological side effects.
K9 Advantix II: Offers the broadest protection (including mosquitoes) but is toxic to cats.
Frontline Plus: Safe for multi-pet households with cats and effective against all flea life stages but slower against ticks.
Citations:
- https://petvm.com/flea-tick/324-simparica-chewable-tablets.html
- https://total.vet/simparica-for-dogs/
- https://www.petstopclinic.com/product/simparica/
- https://www.petcarerx.com/article/frontline-vs-advantix-for-dogs/666
- https://www.petcarerx.com/article/k9-advantix-faqs-everything-you-need-to-know/1313
- https://www.1800petmeds.com/k9+advantix+ii+-prod10631.html
- https://a-z-animals.com/reviews/frontline-plus-for-dogs/
- https://blog.ultimatedog.com/frontline-for-dogs-is-it-really-safe-and-effective/
- https://www.petcarerx.com/simparica/29823
- https://www.goodrx.com/pet-health/dog/frontline-plus-for-dogs
- https://www.dogster.com/ask-the-vet/does-frontline-plus-work
- https://petlearnia.com/pet-medicines-database/frontline-plus/
- https://wagwalking.com/treatment/frontline-plus
- https://www.allivet.com/article/nexgard-vs-simparica.html
- https://vcahospitals.com/know-your-pet/sarolaner
- https://www.webmd.com/pets/pet-meds/simparica-products-fleas-ticks-heartworms
- https://www.petmd.com/pet-medication/simparica-simparicatrio
- https://www.walmart.com/reviews/product/43436804
- https://www.petcarerx.com/k9-advantix-ii-for-dogs/11357/reviews/1
- https://vcahospitals.com/shop/product/k9-advantix-ii
- https://www.petmd.com/pet-medication/frontline
- https://www.reddit.com/r/dogs/comments/cia9jt/help_is_frontline_plus_safe_long_term_what_do_you/
- https://www.entirelypets.com/frontline-plus-side-effects.html
- https://www.petbucket.com/c/4585047/1/simparica-vs-frontline.html
- https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=91fc9ba1-35e6-4e37-8c37-c5e40699bd5b
- https://aminpetshop.com/blogs/news/understanding-simparica-what-is-it
- https://aminpetshop.com/blogs/news/simparica-trio-for-dogs
- https://www.petmd.com/pet-medication/advantage-k9-advantix-ii-and-advantage-multi
- https://www.petbucket.com/blog/62862/the-side-effects-of-advantix-parasite-treatment.html
- https://www.allivet.com/article/nexgard-vs-k9-advantix.html
- https://www.webmd.com/pets/pet-meds/k9-advantix-dogs
- https://www.petbucket.com/c/4585008/1/advantage-vs-advantix.html
- https://texaspetcompany.com/side-effects-of-frontline-plus-for-dogs/
- https://www.vetsupply.com.au/blog/frontline-plus-vs-advantage-which-one-is-better/
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